Overview
EPIC Code:
- LAB373
Soft Test Code:
Send Out Test Code:
- 4646 | 318X
Alternate Names
- Catecholamine Fractionated Urine
- Catecholamine Fractionation, Urinary, Free
- Catecholamines Fractionated, Free (w/out Creatinine)
- Catecholamines, Fractionated, 24-Hour Urine (without Creatinine)
- CATFU
Included Tests
Dopamine, Epinephrine, Norepinephrine, Calculated Total (E + NE)
Clinical Significance
Catecholamines, Fractionated, 24-Hour Urine (without Creatinine) [318X] - The three catecholamines (norepinephrine, epinephrine and dopamine) are the principal secretory products of neural tissue. Clinically, the measurement of circulating catecholamines is valuable in the diagnosis of catecholamine secreting tumors associated chiefly with hypertension (pheochromocytomas, neuroblastomas and gangliomas) and with the evaluation of orthostatic hypotension
Specimen Collection & Preparation
Patient Preparation
It is preferable for the patient to be off medications for a minimum of 18-24 hours prior to collection. However, common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) may cause minimal or no interference.
Patient should avoid tobacco, tea, coffee, and strenuous exercise for 8-12 hours prior to collection.
Specimen Requirements:
-OR-
1.0 mL of a preserved 24-hour random urine in a plastic, 24-hour urine container
Minimum Volume:
0.7 mL of 24-Hour Urine ** This volume does not allow for repeat testing
Specimen Information:
Collection Instructions:
Collect 24-hour urine with 25 mL 6N HCL to maintain a pH ≤3.
If no preservative is used, specimen must be stored refrigerated during collection but shipped frozen and pH must be ≤6.
Record 24-hour urine volume and patient's age on test request form and on urine container.
- When starting the 24-hour period, urinate and discard (throw-away) this specimen.
- NOTE THE TIME From that time on
- Collect all urine by urinating into a clean container and transfer into the provided container.
- DO NOT URINATE DIRECTLY INTO 24 hour jug CONTAINER.
- Try to pass the last urine just prior to the end of the 24 hour period. Add this urine into the container.
- Urine Specimen should be kept refrigerated during and after collection.
Printable Patient Collection Instructions
English 24 Hour Urine Collection
Spanish 24 Hour Urine Collection
Burmese 24 Hour Urine Collection
Arabic 24 Hour Urine Collection
Rejection Criteria:
Preserved urine received refrigerated with pH >3
Ambient Urine
Transport and Storage:
-
Ambient (18-24°C):
Unacceptable
-
Refrigerated (2-8°C):
30 Days
-
Frozen (-20° C or colder):
60 Days
Transport
Clinical Interpretation
Reference Range:
Epinephrine, 24 hr Urine
Pediatric: Not Established
Adult: < or = 24 mcg/24 h
Norepinephrine, 24 hr Urine
Pediatric: Not Established
Adult: < or = 100 mcg/24 h
Calculated Total
Pediatric: Not Established
Adult: 26 - 121 mcg/24 h
Dopamine, 24 hr Urine
Pediatric: Not Established
Adult: 52 - 480 mcg/24 h
Methodology:
- Liquid Chromatography / Mass Spectrometry (LC/MS)
Clinical Significance
Catecholamines, Fractionated, 24-Hour Urine (without Creatinine) [318X] - The three catecholamines (norepinephrine, epinephrine and dopamine) are the principal secretory products of neural tissue. Clinically, the measurement of circulating catecholamines is valuable in the diagnosis of catecholamine secreting tumors associated chiefly with hypertension (pheochromocytomas, neuroblastomas and gangliomas) and with the evaluation of orthostatic hypotension
Production Schedule
Sites Performed
- Quest - Chantilly
Days Performed
Monday
Tuesday
Wednesday
Thursday
Friday
Departments
- Sendouts - Clinical
Turn Around Time
2 to 4 days
Coding & Compliance
CDM
01422773
CPT Coding
82384 CPT code 81050 may be added at an additional charge for volume measurement