Histoplasma Antibodies, IgG and IgM

Last Modified: 12/28/2016 11:05:57 AM

Specimen Requirements: 1.0 mL Serum from a SST Gold Top Tube in a plastic Vial
Collection Instructions: Allow blood to clot for 30 minutes, then centrifuge. Pipette serum into a plastic screw cap vial.
Minimum Volume: 0.5 mL Serum
Transport & Storage: Temperature/Stability: 14 days Ambient 14 days Refrigerated 4 days Frozen
Rejection Criteria: >14 days old
Reference Range: Negative Interpretive Negative: <8.0 EU Intermediate: 8.0 EU-9.9 EU Positive: 10.0 EU-80.0 EU
Methodology: Semi-Quantitative Indirect Enzyme Immunoassay (EIA)
Clinical Significance: IgM and IgG antibodies to Histoplasma antigen usually appear during the first month of infection. The IgM antibody response in acute pulmonary histoplasmosis is detectable during the acute phase (roughly 3 weeks) and is shown to decline during the convalescent stage (at about 6 weeks); whereas, IgG levels remained relatively constant at 6 weeks. Follow-up testing may be considered 2-4 weeks after initial testing to determine if antibody levels are increasing, especially in patients with low positive (10 EU – 20 EU) or intermediate results. Increase in IgG antibody or decrease in IgM concentration would suggest recent infection. Antibodies may persist for several years in patients with chronic pulmonary complications or progressive extrapulmonary (disseminated) histoplasmosis. Antibodies may be falsely-negative in some progressive or chronic cases, especially in immunocompromised patients. Antibodies may also be detected in healthy subjects who are asymptomatic as a result of sub-clinical infection within the last 18-36 months.
Custom Panel: No


Turn Around Time: 1 to 2 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday
Sites Performed: MiraVista
PHL Test Code: MSOT
EPIC Test Code:
Send Out Test Code: 326
Alternate Test Names: Histoplasma Antibodies, IgG and IgM by EIA; Histoplasma Antibody, IgG and IgM by EIA; MVista® HISTOPLASMA ANTIBODY IgG IgM EIA
CPT Coding: 86635 x 2

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