Activated Protein C Resistance

Last Modified: 2/2/2022 1:35:36 PM

Medical Necessity Documentation:
Client Notes:  
Patient Preparation:  
Specimen Requirements:

2.0 mL Frozen Plasma from each of 2 Blue Top Tubes - 3.2% Na Citrate in a 2 Plastic Vials

Collection Instructions:

Centrifuge light blue-top tube 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into four new plastic vials. Plasma must be free of platelets (<10,000/mcL). 

2 separate plastic vials 2.0 mL plasma frozen and sent  

Minimum Volume: 1.0 mL Na Citrate Plasma x2
Transport & Storage: Temperature/Stability:

60 days Frozen

Freeze immediately and ship on dry ice.

Rejection Criteria: Received room temperature • Received refrigerated • Clotted specimen • Serum • Gross hemolysis
Reference Range:

> or = 2.1 Ratio

Critical Ranges:  
Test Comments:  
Methodology: RVVT Based Assay (Clot-based)
Clinical Significance: Individuals with APC have a high risk for developing venous thrombosis.
Custom Panel: No


Turn Around Time: 3 to 6 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Chantilly
PHL Test Code: APCR
EPIC Test Code: LAB2559
Send Out Test Code: 22
Alternate Test Names: Activated Protein C ; Activated Protein C Resistance; APC Resistance, APCR; APC-R
Included Tests:  
CPT Coding: 85307

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