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IDH1 & IDH2 Mutation Analysis
Last Modified:
3/3/2020 1:51:47 PM
Specimen Requirements:
FFPE tissue:
Paraffin block
Collection Instructions:
Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.
Transport & Storage: Temperature/Stability:
Refrigerate, and use cold pack for transport, cold pack should not be in direct contact with specimen
Reference Range:
Refer to Interpretive Results
Methodology:
Molecular
Clinical Significance:
IDH1 or IDH2 mutations are detected in approximately 15-20% of acute myeloid leukemia (AML) and >70% grade II or III brain gliomas. Patients with AML and mutations are likely to have aggressive disease, while mutations in gliomas are associated with better prognosis. Long-term survival after aggressive tumor resection has been reported for patients with IDH1-positive astrocytomas
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
7 to 8 days
Sites Performed:
NeoGenomics
PHL Test Code:
PS
EPIC Test Code:
N/A
Send Out Test Code:
Soft Path - IDH1 & IDH2
Alternate Test Names:
IDH1 Mutation Analysis; IDH2 Mutation Analysis
Included Tests:
IDH1 Mutation Analysis; IDH2 Mutation Analysis
CPT Coding:
81120, 81121
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