MELAS mt DNA Evaluation

Last Modified: 5/17/2019 3:38:57 PM


Medical Necessity Documentation:  
Client Notes: Contact the Laboratory at 266-1500 (Option 1) for the Payment requirements of this test.
Patient Preparation:  
Specimen Requirements: 20.0 mL  Whole Blood in Five Lavender Top Tubes - EDTA
Collection Instructions: Informed Consent Required
Transport & Storage: Temperature/Stability: Refrigerate
Reference Range: No mutation detected
Critical Ranges:  
Test Comments:  
Methodology: Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP)
Clinical Significance: Detects six mtDNA point mutations linked to MELAS syndrome

Type of Disorder: Neuromuscular Disorders 

Typical Presentation: Features may include lactic acidosis, ophthalmoplegia, seizures, stroke-like episodes and ragged red fibers
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 15 to 22 days
Days Performed: Monday, Tuesday, Wednesday, Thursday
Sites Performed: Athena Diagnostics
PHL Test Code: MELS
EPIC Test Code: LAB304094
Send Out Test Code: 517
Alternate Test Names: MELAS
Included Tests: MELAS 3243, MELAS 3252, MELAS 3256, MELAS 3271,  MELAS 3291, and MELAS 13513
CPT Coding: 83891, 83892 x 5, 83898 x 6, 83904, 83909, 83912

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