Actin Antibody IgG

Last Modified: 8/21/2023 1:31:43 PM


Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements:

1.0 mL Serum from a Red Top Tube in a Plastic Vial

Collection Instructions:  
Minimum Volume: 0.25 mLSerum
Transport & Storage: Temperature/Stability: 14 days Ambient
14 days Refrigerated
30 days Frozen
Rejection Criteria: Gross hemolysis • Lipemia • Microbially contaminated serum • Specimens containing heavy, visible particulate
Reference Range: <20 U Negative
> 20 U Positive
Critical Ranges:  
Test Comments:

Antibodies recognizing actin are the main component of smooth muscle antibodies associated with autoimmune liver disease. Actin antibodies are found in approximately 75% of patients with autoimmune hepatitis (AIH) type 1, approximately 65% of patients with autoimmune cholangitis, approximately 30% of patients with primary biliary cirrhosis, and approximately 2% of healthy people. High values are closely correlated with AIH type 1.

 

Methodology: Enzyme Linked Immunosorbent Immunoassay (ELISA)
Clinical Significance:  
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 3 to 5 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday
Sites Performed: Quest - Chantilly
PHL Test Code: SMA1
EPIC Test Code: IMO206
Send Out Test Code: 15043 / 15043X
Alternate Test Names: ACTA; Anti-Smooth Muscle Antibody; Anti-smooth muscle Antibody Titer; ASMA; F-Actin Antibody; SM Muscle Actin Ab; SMA; Smooth Muscle (Actin) Antibody; Smooth Muscle Antibody
Included Tests:  
CPT Coding: 86015

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