HSP-70 Antibody

Overview

  • EPIC Code:
  • Soft Test Code:
  • MSOT
  • Send Out Test Code:
  • 36734
Alternate Names
  • 68 kd Ag
  • 68 kd Antigen
  • 68 Kilodalton Antigen
  • Anti-68 kd Antigen
  • Hearing Loss Ab
  • Heat Shock Protein 70
  • Meniere's Disease
  • Sensorineural Hearing Loss (SNHL)
Clinical Significance

Sensorineural hearing loss (SNHL), commonly referred to as nerve deafness, may be caused by genetic or acquired factors, such as infections, or can be immunologically mediated. A subgroup of idiopathic SNHL cases are treatable with immunosuppressive therapy. The laboratory work up to identify these cases should include serum antibody tests to 68 kD inner ear antigen. Twenty-two percent of patients with bilateral rapidly progressive SNHL and 30% of the patients with Meniere's disease had antibodies that reacted with 68 kD antigen present in the bovine inner ear extracts. Anti-68kD antibodies also occur in approximately 60% of patients with bilateral and 35% of patients with unilateral Meniere's syndrome and 37% of patients with contralateral delayed endolymphatic hydrops.


Specimen Collection & Preparation

Specimen Requirements

1.0 mL Serum in a SST Gold Top Tube


Transport And Storage

7 days Ambient
14 days Refigerated
21 day Frozen

Transport Ambient


Collection Instructions


Minimum Volume

0.5 mL Serum


Neonatal Volume

Clinical Interpretation

Reference Range:

Negative


Methodology:
  • Western blot (WB)
Clinical Significance

Sensorineural hearing loss (SNHL), commonly referred to as nerve deafness, may be caused by genetic or acquired factors, such as infections, or can be immunologically mediated. A subgroup of idiopathic SNHL cases are treatable with immunosuppressive therapy. The laboratory work up to identify these cases should include serum antibody tests to 68 kD inner ear antigen. Twenty-two percent of patients with bilateral rapidly progressive SNHL and 30% of the patients with Meniere's disease had antibodies that reacted with 68 kD antigen present in the bovine inner ear extracts. Anti-68kD antibodies also occur in approximately 60% of patients with bilateral and 35% of patients with unilateral Meniere's syndrome and 37% of patients with contralateral delayed endolymphatic hydrops.


Production Schedule

Sites Performed
  • Quest - Chantilly to San Juan Capistrano
Days Performed
Tuesday
Friday
Departments
  • Sendouts - Miscellaneous
Turn Around Time

6 to 9 days


Coding & Compliance

CDM

00913333


CPT Coding

84181