Sensorineural hearing loss (SNHL), commonly referred to as nerve deafness, may be caused by genetic or acquired factors, such as infections, or can be immunologically mediated. A subgroup of idiopathic SNHL cases are treatable with immunosuppressive therapy. The laboratory work up to identify these cases should include serum antibody tests to 68 kD inner ear antigen. Twenty-two percent of patients with bilateral rapidly progressive SNHL and 30% of the patients with Meniere's disease had antibodies that reacted with 68 kD antigen present in the bovine inner ear extracts. Anti-68kD antibodies also occur in approximately 60% of patients with bilateral and 35% of patients with unilateral Meniere's syndrome and 37% of patients with contralateral delayed endolymphatic hydrops.
1.0 mL Serum in a SST Gold Top Tube
7 days Ambient
14 days Refigerated
21 day Frozen
Transport Ambient
0.5 mL Serum
Negative
Sensorineural hearing loss (SNHL), commonly referred to as nerve deafness, may be caused by genetic or acquired factors, such as infections, or can be immunologically mediated. A subgroup of idiopathic SNHL cases are treatable with immunosuppressive therapy. The laboratory work up to identify these cases should include serum antibody tests to 68 kD inner ear antigen. Twenty-two percent of patients with bilateral rapidly progressive SNHL and 30% of the patients with Meniere's disease had antibodies that reacted with 68 kD antigen present in the bovine inner ear extracts. Anti-68kD antibodies also occur in approximately 60% of patients with bilateral and 35% of patients with unilateral Meniere's syndrome and 37% of patients with contralateral delayed endolymphatic hydrops.
6 to 9 days
00913333
84181