Diazepam

Last Modified: 2/20/2019 4:19:57 PM


Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements:

3.0 mL Serum from a Red Top Tube in a Plastic Vial

Collection Instructions: Do not collect in a Serum Separator Tube (SST or PST)

Let specimen clot for 30 minutes
Centrifuge for 15 minutes
Immediately transfer serum into plastic vial
Minimum Volume: 1.0 mL
Transport & Storage: Temperature/Stability: 1 week Refrigerated
Reference Range:

0.5 - 1.0 mcg/mL

Critical Ranges: 1.0 mcg/mL (combination of Diazepam and Nordiazepam))
Test Comments: Detect use • Evaluate therapeutic effect or possible toxicity
Methodology: GC/MS
Clinical Significance: Diazepam (Valium®, Valrelease) is the second benzodiazepine derivative to have been approved for human usage (1963) and has been one of the most frequently prescribed drugs in the United States. It is administered as an antianxiety agent, muscle relaxant, or anticonvulsant, orally or by intramuscular or intravenous injection, in single doses of 2-20 mg and up to 40 mg daily. Diazepam undergoes N-demethylation to nordiazepam, a metabolite at least as active as its parent. Overdosage with diazepam generally results in drowsiness, ataxia, and muscular weakness. Chronic usage may cause physical dependence, and grand mal seizures can occur upon withdrawal.
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 3 to 5 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday
Sites Performed: South Bend Medical Foundation
PHL Test Code: DIAD
EPIC Test Code: LAB468
Send Out Test Code: 44964
Alternate Test Names: Valium
Included Tests: Diazepam; Nordiazepam
CPT Coding: 80346

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