KRAS Exon 4 Mutation Analysis

Last Modified: 3/3/2020 3:07:40 PM

Specimen Requirements:

FFPE tissue: Paraffin block

Collection Instructions: Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.
Transport & Storage: Temperature/Stability:  Refrigerate, and use cold pack for transport, cold pack should not be in direct contact with specimen.
Reference Range: Refer to Interpretive Results
Methodology: Molecular
Clinical Significance:

This assay complements the standard KRAS Mutation Analysis of exons 2 and 3. Mutations in exon 4 are detected in approximately 1-4% of colorectal cancers. Exon 4 analysis is appropriate for detecting activating mutations that may confer resistance to EGFR-targeted inhibitors and predicts sensitivity to MEK inhibition.

Custom Panel: No


Turn Around Time: 7 to 8 days
Sites Performed: NeoGenomics
PHL Test Code: PS
EPIC Test Code: N/A
Send Out Test Code: Soft Path - KRAS4
Alternate Test Names: KRAS Exon 4 Sequencing; KRAS Exon-4 Mutation Analysis
CPT Coding: 81276

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