CML/ALL, bcr/abl, Translocation 9;22

Last Modified: 12/31/2020 9:00:44 AM

Medical Necessity Documentation:  
Patient Preparation:  
Specimen Requirements:

5.0 mL Whole Blood in two Green Top Tubes - Na Heparin

Collection Instructions: Clinical history and reason for referral are required with test order. Prior therapy and bone marrow transplant history should be provided with test order.

Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination. Do not freeze. Do not reject.

Note: If results are not possible, the test order may be canceled and replaced by a "Cytogenetics Communication".
Minimum Volume: 3 mL Whole Blood
Transport & Storage: Temperature/Stability: 24 hours Ambient
Rejection Criteria: Frozen
Reference Range: Refer to Interpretive Results
Critical Ranges:  
Test Comments:  
Methodology: Fluorescence in situ Hybridization (FISH)
Clinical Significance:

FISH, CML/ALL, bcr/abl, Translocation 9;22 - This test is performed to detect the molecular rearrangement of the BCR and ABL1 genes involved in translocation t(9;22) associated with chronic myelogenous leukemia (CML), acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML) using FISH (fluorescence in situ hybridization). This test may be used in the evaluation of Ph negative CML, complex rearrangements or for follow up to therapy for previously diagnosed Ph+ patients

Custom Panel: No


Turn Around Time: 5 to 7 days
Days Performed: Sunday, Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Chantilly
PHL Test Code: BCRXX
EPIC Test Code: LAB3190
Send Out Test Code: 12070
Alternate Test Names: ALL; Chronic Myelogenous Leukemia (CML) Blast Crisis; CML; FISH, CML/ALL, bcr/abl, Translocation 9;22
Included Tests:  
CPT Coding: 88271 x 2, 88275

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