BCR/ABL: T(9;22)

Last Modified: 9/15/2022 6:19:14 AM


Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements:

5.0 mL Bone Marrow in Green Top Tubes - Na Heparin
Collection Instructions: Place bone marrow (2 ml req.) into tube, label with patient's name. Send in bone marrow kit 
Minimum Volume: 3 mL Whole Blood
Transport & Storage: Temperature/Stability: 72 hours Refrigerated

  Specimen has a 72 hour stability.  Specimens must arrive at PRMC in the Sendout Department by 4 p.m. if collected on a Friday.
Reference Range: Refer to Interpretive Results
Critical Ranges:  
Test Comments:  
Methodology: Fluorescence in situ Hybridization (FISH)
Clinical Significance: FISH for BCR/ABL is used to diagnose CML, is a prognostic indicator for B-cell Lymphoblastic Leukemia/Lymphoma, and is used to monitor patient response to tyrosine kinase inhibitor therapy. Before initiating treating with a TKI it may be helpful to order ABL Kinase analysis in order to better inform on which TKI to utilize.

 
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 3 to 5 days
Sites Performed: GenPath Diagnostics
PHL Test Code: BCRFI
EPIC Test Code: LAB3235
Send Out Test Code: 5265-4
Alternate Test Names: BCR/ABL: T(9;22) by FISH; Philadelphia Chromosome Analysis
Included Tests:  
CPT Coding: 88374

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