Coccidioides Antibody, IgG and IgM

Last Modified: 2/20/2019 3:24:40 PM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 1.0 mL Serum from a SST Gold Top Tube
Collection Instructions: Allow blood to clot for 30 minutes, then centrifuge. 
Pipette serum into a plastic screw cap via
Minimum Volume: 0.5 mL Serum
Transport & Storage: Temperature/Stability: 14 days Refrigerated
14 days Frozen
Reference Range:


Negative: <8.0 EU
Intermediate: 8.0 EU – 9.9 EU
Positive: 10.0 EU – >80.0 EU

Critical Ranges:  
Test Comments: Limitations: 
 8% cross reactivity with Blastomyosis
36% cross reactivity with Histoplasmosis
Methodology: Semi-Quantitative Indirect Enzyme Immunoassay (EIA)
Clinical Significance: IgM and IgG antibodies to Coccidioides antigen usually appear during the first month of infection, decline over the next 3-6 months but remain detectable for approximately 18-24 months in some cases with self-limited illnesses. Antibodies may persist in patients with chronic pulmonary complications or progressive extrapulmonary (disseminated) coccidioidomycosis. Antibodies may be falsely-negative in some progressive or chronic cases. Follow-up testing maybe considered at weeks 2 – 4 to determine if antibody levels are increasing especially in patients with low positive (10 EU – 20 EU) or intermediate results. Increase in antibody concentration would suggest recent infection. Antibodies may also be detected in healthy subjects who are asymptomatic as a result of sub-clinical infection within the last 18 – 36 months.
Custom Panel: No


Turn Around Time: 1 to 2 days
Days Performed: Monday, Thursday
Sites Performed: MiraVista
PHL Test Code: COCCI
EPIC Test Code: IMO4183
Send Out Test Code: 325
Alternate Test Names: COCCIDIOIDES AB IGG IGM EIA; Coccidioides Antibody, IgG & IgM; Coccidioides Antibody, IgG and IgM EIA
Included Tests:  
CPT Coding: 86635 x 2

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