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Coccidioides Antibody, IgG and IgM
Last Modified:
5/30/2023 7:06:02 AM
Medical Necessity Documentation:
Client Notes:
Patient Preparation:
Specimen Requirements:
1.0 mL Serum from a SST
Gold Top Tube
Collection Instructions:
Allow blood to clot for 30 minutes, then centrifuge.
Pipette serum into a plastic screw cap via
Minimum Volume:
0.5 mL Serum
Transport & Storage: Temperature/Stability:
14 days Refrigerated
14 days Frozen
Reference Range:
Negative
Negative:
<1.0 EU
Positive:
>
1.0 EU
Critical Ranges:
Test Comments:
Limitations:
8% cross reactivity with Blastomyosis
36% cross reactivity with Histoplasmosis
Methodology:
Semi-Quantitative Indirect Enzyme Immunoassay (EIA)
Clinical Significance:
IgM and IgG antibodies to Coccidioides antigen usually appear during the first month of infection, decline over the next 3-6 months but remain detectable for approximately 18-24 months in some cases with self-limited illnesses. Antibodies may persist in patients with chronic pulmonary complications or progressive extrapulmonary (disseminated) coccidioidomycosis. Antibodies may be falsely-negative in some progressive or chronic cases. Follow-up testing maybe considered at weeks 2 – 4 to determine if antibody levels are increasing especially in patients with low positive (10 EU – 20 EU) or intermediate results. Increase in antibody concentration would suggest recent infection. Antibodies may also be detected in healthy subjects who are asymptomatic as a result of sub-clinical infection within the last 18 – 36 months.
Documentation:
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
1 to 2 days
Days Performed:
Monday, Wednesday, Thursday, Friday
Sites Performed:
MiraVista
PHL Test Code:
COCCI
EPIC Test Code:
IMO4183
Send Out Test Code:
325
Alternate Test Names:
COCCIDIOIDES AB IGG IGM EIA; Coccidioides Antibody, IgG & IgM; Coccidioides Antibody, IgG and IgM EIA
Included Tests:
CPT Coding:
86635 x 2
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