Client Notes:
Include a copy of insurance cards
Specimen Requirements:
2.0 mL Bone Marrow in a Green Top Tube - Na Heparin
Collection Instructions:
Clinical history and reason for referral are required with test order. Prior therapy and transplant history should be provided with test order.
Minimum Volume:
1.0 mL
Transport & Storage: Temperature/Stability:
Ambient (transport)
Refrigerated
Rejection Criteria:
Frozen Specimen
Reference Range:
Refer to Interpretive Results
Methodology:
Fluorescence in situ Hybridization (FISH)
Clinical Significance:
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders, characterized by ineffective maturation of the myeloid cells of the bone marrow. Among MDS patients, 45-40% have at least one chromosome rearrangement, the most common of which can be detected using this fluorescence in situ hybridization (FISH) panel (-5/5q-, -7/7q-, +8, 20q-).
This panel of FISH probes can increase the detection rate of chromosome abnormalities at diagnosis and aid in follow-up testing for clinically significant chromosome abnormalities in MDS.
The identification of the specific chromosome regions involved in a patient's disease may play a significant role in treatment decisions as MDS targeted therapies are developed.
Documentation:
Four probe sets associated with myelodysplastic syndrome (MDS) are included in this panel: -5/5q-, -7/7q-, +8, 20q-. 100-300 interphase nuclei are scored for each probe set to detect gain, loss, or rearrangements of the probe regions
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
4 to 7 days
Days Performed:
Monday, Tuesday, Wednesday, Thursday
Sites Performed:
Quest - Chantilly
PHL Test Code:
MDSF
EPIC Test Code:
LAB3069
Send Out Test Code:
19799
Alternate Test Names:
5q33.34 (5q deletion), 7q31 (7q deletion), Trisomy; Acute Myelogenous Leukemia (AML); FISH, MDS/Myeloid Panel, -5/5q-, -7/7q-, +8,20q- ; MDS FISH Profile; MDS Panel (+8, -5/5q-, -7/7q-, 20q-); Myelodysplastic Syndrome (MDS) Panel ; Myelodysplastic Syndrome FISH Profile; Myeloproliferative Disorders (MPD); Oncology FISH Analysis - MDS FISH Panel
CPT Coding:
88275 x 3, 88271 x 6