FISH, MDS/Myeloid Panel, -5/5q-, -7/7q-, +8,20q-

Last Modified: 9/19/2019 1:49:25 PM

Client Notes: Include a copy of insurance cards
Specimen Requirements:

5.0 mL Whole Blood in a Green Top Tube(s) - Li Heparin

Collection Instructions: Clinical history and reason for referral are required with test order. Prior therapy and transplant history should be provided with test order.
Minimum Volume: 1.0 mL
Transport & Storage: Temperature/Stability: Ambient (transport)
Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination. Do not freeze. Do not reject.
Rejection Criteria: Frozen Specimen
Reference Range: Refer to Interpretive Results
Methodology: Fluorescence in situ Hybridization (FISH)
Clinical Significance:

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders, characterized by ineffective maturation of the myeloid cells of the bone marrow. Among MDS patients, 45-40% have at least one chromosome rearrangement, the most common of which can be detected using this fluorescence in situ hybridization (FISH) panel (-5/5q-, -7/7q-, +8, 20q-).

This panel of FISH probes can increase the detection rate of chromosome abnormalities at diagnosis and aid in follow-up testing for clinically significant chromosome abnormalities in MDS.

The identification of the specific chromosome regions involved in a patient's disease may play a significant role in treatment decisions as MDS targeted therapies are developed.

Documentation: Four probe sets associated with myelodysplastic syndrome (MDS) are included in this panel: -5/5q-, -7/7q-, +8, 20q-. 100-300 interphase nuclei are scored for each probe set to detect gain, loss, or rearrangements of the probe regions
Custom Panel: No


Turn Around Time: 4 to 7 days
Days Performed: Monday, Tuesday, Wednesday, Thursday
Sites Performed: Quest - Chantilly
PHL Test Code: MDSF
EPIC Test Code: LAB3069
Send Out Test Code: 19799
Alternate Test Names: 5q33.34 (5q deletion), 7q31 (7q deletion), Trisomy; Acute Myelogenous Leukemia (AML); FISH, MDS/Myeloid Panel, -5/5q-, -7/7q-, +8,20q- ; MDS FISH Profile; MDS Panel (+8, -5/5q-, -7/7q-, 20q-); Myelodysplastic Syndrome (MDS) Panel ; Myelodysplastic Syndrome FISH Profile; Myeloproliferative Disorders (MPD); Oncology FISH Analysis - MDS FISH Panel
CPT Coding: 88275 x 3, 88271 x 6

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