Aspirin Response

Overview

  • EPIC Code:
  • LAB2443
  • Soft Test Code:
  • ASA
Alternate Names
  • ASA
Included Tests

Collagen EPI; Collagen ADP


Clinical Significance

Coll/EPI           Coll/ADP
<=173 sec      Not Done
Platelet Function appears adequate. Result consistent with no aspirin ingestion or patient is an Aspirin Non-Responder.
 
Coll/ EPI          Coll/ADP
>173 sec         <=126 sec
Results consistent with those of an Aspirin Responder or recent ingestion of antiplatelet medications. Also consistent with any of the following: mild thrombocytopenia, low hematocrit, mild platelet dysfunction or mild von Willebrand disease.
 
Coll/EPI          Coll/ADP
>173 sec         >126 sec
Results consistent with those of an Aspirin Responder or recent ingestion of antiplatelet medications. Also consistent with any of the following or combination of: thrombocytopenia, low hematocrit, platelet dysfunction, von Willebrand disease.  Additional follow-up may be warranted if clinically indicated. 


Specimen Collection & Preparation

Client Notes

Prior to collection, please contact PHL Client Response at 266-1500 (Option 2) to request a Stat courier to maintain the integrity and stability of the specimen. 

If specimen cannot get to Parkview Regional Medical Center (PRMC) within 3 hours of collection, please send the patient to PRMC to be drawn at 11109 Parkview Plaza, Entrance 3. 


Specimen Requirements:

-OR-

5.4 mL Whole Blood in two (2) Blue Top Tubes - 3.2% Sodium Citrate
Collection Instructions:

Collect using a 21G or larger (20G or 19G) needle.

Collection tubes must be filled to the recommended fill line as specified by the tube manufacturer.


Rejection Criteria:

Specimens that have been centrifuged MUST be recollected.

Specimens that have been refrigerated, chilled on ice, or frozen MUST be recollected.

Specimens must be tested within 4 hours of collection- recollect if stability time is exceeded.

Hemolyzed or clotted samples are unacceptable.


Transport and Storage:
  • Ambient (18-24°C): 4 Hours

    Specimens must be received at testing site within 3 hours of collection.

Clinical Interpretation

Reference Range:

Collagen/EPI: 69 - 173 seconds
 
Collagen/ADP: 54 - 126 seconds

Coll/EPI          Coll/ADP
<=173 sec       Not Done
Platelet Function appears adequate. Result consistent with no aspirin ingestion or patient is an Aspirin Non-responder. The effects of ADP receptor blockers such as Clopidogrel are unpredictable.
Coll/EPI           Coll/ADP
>173 sec         <=126 sec
Results consistent with those of an Aspirin Responder or recent ingestion of antiplatelet medications. Also consistent with any of the following: mild thrombocytopenia, low hematocrit, mild platelet dysfunction, mild von Willebrand disease.  The effects of ADP receptor blockers such as Clopidogrel are unpredictable.
 Coll/EPI            Coll/ADP
>173 sec           >126 sec
Results consistent with those of an Aspirin Responder or recent ingestion of antiplatelet medications, such as GPllb/llla receptor inhibitors.Also consistent with any of the following: thrombocytopenia, low hematocrit, platelet dysfunction, von Willebrand disease.  The effects of ADP receptor blockers such as Clopidogrel are unpredictable. Additional follow up may be warranted if clinically indicated.


Test Comments:

Collagen/EPI will always be performed. If Collagen/EPI is > 173 seconds, Collagen/ADP testing will be performed.


Methodology:
  • Platelet Function Analyzer
Clinical Significance

Coll/EPI           Coll/ADP
<=173 sec      Not Done
Platelet Function appears adequate. Result consistent with no aspirin ingestion or patient is an Aspirin Non-Responder.
 
Coll/ EPI          Coll/ADP
>173 sec         <=126 sec
Results consistent with those of an Aspirin Responder or recent ingestion of antiplatelet medications. Also consistent with any of the following: mild thrombocytopenia, low hematocrit, mild platelet dysfunction or mild von Willebrand disease.
 
Coll/EPI          Coll/ADP
>173 sec         >126 sec
Results consistent with those of an Aspirin Responder or recent ingestion of antiplatelet medications. Also consistent with any of the following or combination of: thrombocytopenia, low hematocrit, platelet dysfunction, von Willebrand disease.  Additional follow-up may be warranted if clinically indicated. 


Production Schedule

Sites Performed
  • Parkview Regional Medical Center
Days Performed
Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Departments
  • Coagulation
Turn Around Time

4 hours


Stat Eligible

Coding & Compliance

CDM

01455576 (Reflex 01455577)


CPT Coding

85576 (Reflex 85576)