Aspirin Response

Last Modified: 2/13/2019 12:26:49 PM


Medical Necessity Documentation:  
Client Notes: Prior to your collection please contact PHL Client Response at 266-1500 (Option 2) to request a Stat courier to maintain the integrity and stability of the specimen. 

If specimen can not reach Parkview Regional Medical Center (PRMC) within 3 hours of collection, please send the patient to PRMC to be drawn at 11109 Parkview Plaza Entrance 3. 
Patient Preparation:  
Specimen Requirements: 5.4 mL Whole Blood in two (2) Blue Top Tubes - 3.2% Sodium Citrate
Collection Instructions: Collect this specimen with a 21G needle
Transport & Storage: Temperature/Stability: 4 hours Ambient - Specimen must be received at testing site within 3 hours of collection
Rejection Criteria: Centrifuged; Refrigerated; Frozen
Reference Range:
Collagen/EPI: 69 - 173 Seconds
 
Collagen/ADP: 54 - 126 Seconds

Coll/EPI          Coll/ADP
< =173 sec     Not Done
Platelet Function appears adequate. Result consistent with no aspirin ingestion or patient is an Aspirin Non-responder. The effects of ADP receptor blockers such as Clopidogrel are unpredictable.
Coll/EPI           Coll/ADP
>173 sec        <=126 sec
Results consistent with those of an Aspirin Responder or recent ingestion of antiplatelet medications. Also consistent with any of the following: mild thrombocytopenia, low hematocrit, mild platelet dysfunction, mild von Willebrand disease.  The effects of ADP receptor blockers such as Clopidogrel are unpredictable.
 Coll/EPI            Coll/ADP
>173 sec         >126 sec
Results consistent with those of an Aspirin Responder or recent ingestion of antiplatelet medications, such as GPllb/llla receptor inhibitors.Also consistent with any of the following: thrombocytopenia, low hematocrit, platelet dysfunction, von Willebrand disease.  The effects of ADP receptor blockers such as Clopidogrel are unpredictable. Additional follow up may be warranted if clinically indicated.
Critical Ranges:  
Test Comments: Collagen/EPI will always be performed. If Collagen/EPI is >173 sec, Collagen/ADP testing will be performed.
Methodology: Platelet Function Analyzer
Clinical Significance:
Coll/EPI        Coll/ADP
< =173 sec      Not Done
Platelet Function appears adequate. Result consistent with no aspirin ingestion or patient is an Aspirin Non-Responder.
 
Coll/ EPI        Coll/ADP
>173 sec        <=126 sec
Results consistent with those of an Aspirin Responder or recent ingestion of antiplatelet medications. Also consistent with any of the following: mild thrombocytopenia, low hematocrit, mild platelet dysfunction or mild von Willebrand disease.
 
 Coll/EPI        Coll/ADP
>173 sec         >126 sec
Results consistent with those of an Aspirin Responder or recent ingestion of antiplatelet medications. Also consistent with any of the following or combination of: thrombocytopenia, low hematocrit, platelet dysfunction, von Willebrand disease.  Additional follow-up may be warranted if clinically indicated. 
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Stat Eligible: Yes
Days Performed: Sunday, Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Parkview Regional Medical Center
PHL Test Code: ASA
EPIC Test Code: LAB2443
Alternate Test Names: ASA
Included Tests: Collagen ADP; Collagen EPI
CPT Coding: 85576 (Reflex 85576)

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