Parietal Cell Antibody

Last Modified: 8/21/2023 2:46:39 PM


Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements:

1.0 mL Serum in a SST Gold Top Tube
Collection Instructions:  
Minimum Volume: 0.3 mL
Transport & Storage: Temperature/Stability:

14 days Refrigerated
30 days Frozen
Rejection Criteria: Gross hemolysis • Grossly lipemic
Reference Range: Negative: < or = 20.0 Units
Equivocal: 20.1 - 24.9 Units
Positive: > or = 25.0 Units
Critical Ranges:  
Test Comments: Anti-gastric parietal cell antibodies (Anti-GPA) were previously tested for by indirect immunofluorescence assay (IFA), using mouse stomach as a substrate. Identification of the specific antibody target as H+/K ATPase protein (a gastric proton pump) has led to the development of an ELISA based assay. Antibodies to this protein are present in approximately 80% of patients with pernicious anemia and a small percentage of the general adult population. The latter percentage increases with age and may reflect the presence of atrophic gastritis. A negative test does not exclude a diagnosis of pernicious anemia. A test for
intrinsic factor blocking antibody (IFab) may provide serological evidence in support of the diagnosis in some of these patients.
Methodology: Enzyme Linked Immunosorbent Assay
Clinical Significance:  
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 1 to 4 days
Days Performed: Tuesday, Thursday, Saturday
Sites Performed: Quest - Chantilly
PHL Test Code: PARI3
EPIC Test Code: IMO207
Send Out Test Code: 15114
Alternate Test Names: Anti-Parietal Cell Antibody; Gastric Parietal Cell Antibody
Included Tests:  
CPT Coding: 83516

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