F2-Isoprostane/Creatinine Ratio

Last Modified: 1/30/2020 2:38:16 PM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 8.0 mL Urine in a Yellow Capped Tube 
Collection Instructions:

1. Collect random urine in preservative-free urine collection container (cup).
2. Transfer 2 mL urine sample into the preservative-free urine transport tube.
3. Store and transport refrigerated. Please discard urine collection container

Minimum Volume: 1.5 mL Urine
Transport & Storage: Temperature/Stability: 48 hours Ambient

7 days Refrigerated (Transport)

6 months Frozen -20° & -70°
Rejection Criteria: Specimens other than preservative-free urine; improper labeling; samples not stored properly; samples older than stability limits
Reference Range: <0.86 ng/mg Creatinine
Critical Ranges:  
Test Comments:  
Methodology: LC MS/MS
Clinical Significance: The F2-isoprostane/creatinine is the “gold standard” for measuring oxidative stress and has utility in individuals who have lifestyle risks due to poor diet or smoking, a family history of cardiovascular disease, or hyperlipidemia. High levels are seen in conditions associated with increased risk of atherosclerosis and certain cancers. 

Conditions that result in excessive generation of free radicals, including atherosclerosis, smoking and alcoholism, can result in increased levels of urinary isoprostanes. 

The measurement of urinary isoprostanes is also used to assess efficacy of antioxidants in vivo.
Custom Panel: No


Turn Around Time: 3 to 6 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Chantilly to Cleveland HeartLab Inc.
Other Testing Facility: Cleveland HeartLab, Inc.
PHL Test Code: F2ICR
EPIC Test Code: LAB3098
Send Out Test Code: 92771
Alternate Test Names: F2 - Isoprostane/Creatinine Ratio; F2 Isoprostane; F2-IsoPs ; IsoPF2
Included Tests: F2-isoprostane, Urine Creatinine
CPT Coding: 82542, 82570

Go back to the top of the page.