The presence of E6/E7 messenger RNA from 14 high risk HPV types indicates incorporation of HPV DNA into the host cells. Proteins expressed from E6/E7 polycistronic mRNA alter cellular p53 and retinoblastoma protein functions, leading to disruption of cell-cycle check points and cell genome instability. This information, together with the physician's assessment of cytology history, other risk factors, and professional guidelines, may be used to guide patient management. This assay detects E6/E7 viral messenger RNA (mRNA) from 14 high-risk HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68).
5 mL Liquid Cytology (PreservCyt®) Preservative (ThinPrep®) collected in an APTIMA® transport tube
30 days Ambient (transport)
90 days Refrigerated
Labs performing cytology: Aliquot PreservCyt® solution before or after performance of liquid based cytology testing.
PreservCyt®: Transfer 1 mL of PreservCyt® solution into APTIMA® Vaginal Collection tube (orange label) or APTIMA® Specimen Transfer tube (green label). Ship to lab.
1.0 mL Liquid Cytology
| HPV mRNA E6/E7 | Not detected |
This test was performed using the APTIMA® HPV Assay (Gen-Probe Inc.).
This assay detects E6/E7 viral messenger RNA (mRNA) from 14 high-risk HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68).
If HPV mRNA E6/E7 is detected, HPV Genotypes 16, 18/45 will be performed at an additional charge (CPT Code(s): 87625).
The presence of E6/E7 messenger RNA from 14 high risk HPV types indicates incorporation of HPV DNA into the host cells. Proteins expressed from E6/E7 polycistronic mRNA alter cellular p53 and retinoblastoma protein functions, leading to disruption of cell-cycle check points and cell genome instability. This information, together with the physician's assessment of cytology history, other risk factors, and professional guidelines, may be used to guide patient management. This assay detects E6/E7 viral messenger RNA (mRNA) from 14 high-risk HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68).
2 to 3 days
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