Glutamic Acid Decarboxylase Autoantibodies

Last Modified: 9/3/2019 12:18:11 PM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 1.0 mL Serum from a Red Top Tube in a Plastic Vial
Collection Instructions:  
Minimum Volume: 0.5 mL Serum
Transport & Storage: Temperature/Stability: 7 days Ambient (Transport)
14 days Refrigerated
60 days Frozen
Rejection Criteria: Hemolysis, Lipemia, and reject due to thawing or any other rejections; room temperature
Reference Range: <5 IU/mL
Critical Ranges:  
Test Comments:  Limitations GAD-65 antibodies are detected in 20% of diabetic twins who remain disease-free for long periods of time and in 8% of healthy individuals.
Methodology: Enzyme Linked Immunosorbent Assay (ELISA)
Clinical Significance: Glutamic acid decarboxylase (GAD-65) antibody is useful to diagnose insulin dependent diabetes mellitus [Type I diabetes (autoimmune-mediated diabetes)] to assess risk for development of Type I diabetes, to predict onset of Type I diabetes, and risk of development of related endocrine disorders, e.g., thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells, and by circulating autoantibodies against a variety of islet cell antigens, including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin (IAA).
Custom Panel: No


Turn Around Time: 3 to 5 days
Days Performed: Sunday, Monday, Tuesday, Wednesday, Thursday, Friday
Sites Performed: Quest - Chantilly
PHL Test Code: GLUT1
EPIC Test Code: LAB650
Send Out Test Code: 34878
Alternate Test Names: Anti-GAD; GAD; GAD-65; Glutamic Acid Decarboxylase Autoabs; Glutamic Acid Decarboxylase-65 Ab; Glutamic Acid Decarboxylase-65 Antibody
CPT Coding: 86341

Go back to the top of the page.