FISH, Myeloma, 17p-, rea 14q32 with Reflexes

Last Modified: 12/9/2019 1:46:20 PM

Specimen Requirements:

3.0 mL Bone Marrow in a Green Top Tube - Na Heparin

Collection Instructions: 3 mL bone marrow aspirate submitted in culture transport media
Minimum Volume: 1.0 mL Bone Marrow
Transport & Storage: Temperature/Stability: Ambient (Transport)

Specimen viability decreases during transit. Send specimen to testing lab for viability determination, do not reject
Rejection Criteria: Frozen
Reference Range: Refer to Interpretive Results
Test Comments: When the result for IGH rearrangement is positive during initial FISH analysis, the IGH Panel (MAFB, MAF, FGFR3, CCND1) will be performed at an additional charge (CPT code(s): 88271 (x8), 88275 (x4)).
This allows identification of high risk t(14;16) and t(14;20), intermediate risk t(4;14), and standard risk t(11;14).
Methodology: Fluorescence in situ Hybridization (FISH)
Clinical Significance: Plasma cell myeloma (PCM) is characterized by the proliferation of malignant monoclonal plasma cells in the bone marrow. Initial FISH testing is performed to detect high risk rearrangements of IGH (14q32) and deletion of TP53 (17p13.1). The prognostic panel also includes probes to detect gains of 1q and monosomy or deletion 13q associated with less favorable outcome and gains of chromosome 9, 11, and 15 associated with more favorable outcome.
Custom Panel: No


Turn Around Time: 8 to 9 days
Days Performed: Sunday, Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Chantilly
PHL Test Code: FISHM
EPIC Test Code: LAB3070
Send Out Test Code: 92497
Alternate Test Names: FISH, MYELOMA
Included Tests: FISH, Myeloma, 17p-, rea 14q32; FISH, Myeloma; Risk Assessment Panel


CPT Coding: 88275 x 5, 88271 x 4

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