ADAMTS13 Activity with Reflex to Inhibitor [14532X] - ADAMTS-13 is a zinc metalloprotease that cleaves ultra large vWF multimers. Studies have shown that low levels of ADAMTS-13 activity are associated with thrombotic thrombocytopenic purpura (TTP), a life-threatening hematological condition characterized by a low platelet count, microvascular thrombi, red cell fragmentation, and renal complications. Congenital TTP is a rare inherited disease caused by mutations within the ADAMTS-13 gene, which result in the production of non-functional protein. The acquired form of TTP is an autoimmune-like disorder caused by the development of autoantibodies to ADAMTS-13 that inhibits enzyme activity
1.0 mL Frozen Platelet Poor Plasma from a Blue Top Tube - 3.2% Na Citrate in a Plastic Vial
Unacceptable Ambient
Unacceptable Refrigerated
21 days Frozen -20° (Transport)
Please submit a separate, frozen vial for each special coagulation assay ordered.
Platelet-poor plasma: Draw blood in a light blue-top tube containing 3.2% sodium citrate, mix gently by inverting 3-4 times. Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial.
Freeze immediately and ship on dry ice.
Please submit a separate, frozen vial for each special coagulation assay ordered.
0.5 mL Frozen Platelet Poor Plasma
| ADAMTS13 Activity | 68-163 % Activity |
| ADAMTS13 Inhibitor | <0.4 BEU |
If ADAMTS13 Activity is ≤30, then ADAMTS13 Inhibitor will be performed at an additional charge (CPT code(s): 85335)
ADAMTS13 Activity with Reflex to Inhibitor [14532X] - ADAMTS-13 is a zinc metalloprotease that cleaves ultra large vWF multimers. Studies have shown that low levels of ADAMTS-13 activity are associated with thrombotic thrombocytopenic purpura (TTP), a life-threatening hematological condition characterized by a low platelet count, microvascular thrombi, red cell fragmentation, and renal complications. Congenital TTP is a rare inherited disease caused by mutations within the ADAMTS-13 gene, which result in the production of non-functional protein. The acquired form of TTP is an autoimmune-like disorder caused by the development of autoantibodies to ADAMTS-13 that inhibits enzyme activity
2 to 5 days
00915397, 00915335
85397