Estrogens are responsible for the development of the secondary female sex characteristics. Together with gestagens they control all the important female reproductive processes.
The biologically most active estrogen is 17β-estradiol. This is a steroid hormone having a molecular weight of 272 daltons.
Estrogens are produced primarily in the ovary (follicle, corpus luteum), but small quantities are also formed in the testes and in the adrenal cortex. During pregnancy, estrogens are mainly formed in the placenta. About 98 % of estradiol is bound to transport proteins (SHBG = sex hormone binding globulin).
Estrogen secretion is biphasic during the menstrual cycle. The determination of estradiol is utilized clinically in the elucidation of fertility disorders in the hypothalamus-pituitary-gonad axis, gynecomastia, estrogen-producing ovarian and testicular tumors and in hyperplasia of the adrenal cortex. Further clinical indications are the monitoring of fertility therapy and determining the time of ovulation within the framework of in vitro fertilization (IVF).
The Elecsys Estradiol III assay employs a competitive test principle using two monoclonal antibodies specifically directed against 17β-estradiol. Endogenous estradiol released from the sample by mesterolone competes with the added estradiol derivative labeled with a ruthenium complex for the binding sites on the biotinylated antibody.
Patient should discontinue taking Biotin, Vitamin B7, or Vitamin H 48 hours before getting blood drawn.
* This volume does not allow for repeat testing
Use of fulvestrant (Faslodex®) may cause falsely elevated Estradiol results. Estradiol (LC/MS) should be used to measure Estradiol concentrations in cases where fulvestrant is being administered.
Patients taking vitamin supplements containing high doses of biotin (> 5 mg/day) may have falsely increased test results generated.
Estrogens are responsible for the development of the secondary female sex characteristics. Together with gestagens they control all the important female reproductive processes.
The biologically most active estrogen is 17β-estradiol. This is a steroid hormone having a molecular weight of 272 daltons.
Estrogens are produced primarily in the ovary (follicle, corpus luteum), but small quantities are also formed in the testes and in the adrenal cortex. During pregnancy, estrogens are mainly formed in the placenta. About 98 % of estradiol is bound to transport proteins (SHBG = sex hormone binding globulin).
Estrogen secretion is biphasic during the menstrual cycle. The determination of estradiol is utilized clinically in the elucidation of fertility disorders in the hypothalamus-pituitary-gonad axis, gynecomastia, estrogen-producing ovarian and testicular tumors and in hyperplasia of the adrenal cortex. Further clinical indications are the monitoring of fertility therapy and determining the time of ovulation within the framework of in vitro fertilization (IVF).
The Elecsys Estradiol III assay employs a competitive test principle using two monoclonal antibodies specifically directed against 17β-estradiol. Endogenous estradiol released from the sample by mesterolone competes with the added estradiol derivative labeled with a ruthenium complex for the binding sites on the biotinylated antibody.
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