Hepatitis C Viral RNA Genotype 1 NS5b Drug Resistance

Last Modified: 3/27/2019 3:03:20 PM


Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 2.0 mL Plasma from a Lavender Top Tube - EDTA in a Plastic Vial
Collection Instructions: Separate plasma from whole blood within 24 hours of collection by centrifugation. Transfer to a plastic, screw-cap vial and refrigerate or freeze.
Minimum Volume: 0.6 mL Plasma
Transport & Storage: Temperature/Stability: 72 hours Ambient
14 days Refrigerated
42 days Frozen
Rejection Criteria: Gross hemolysis • Gross lipemia • Specimens collected using heparin as anticoagulant
Reference Range:
HCV NS5b Subtype Not detected
Critical Ranges:  
Test Comments:  
Methodology: Polymerase Chain Reaction (PCR) • Sequencing
Clinical Significance: For detection of mutations in the Genotype 1 NS5b gene associated with resistance to nucleotide analog NS5b polymerase inhibitors (example: sofosbuvir, a nucleotide analog inhibitor of HCV NS5b polymerase).
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 5 to 12 days
Days Performed: Tuesday
PHL Test Code: HC15B
EPIC Test Code: LAB3012
Send Out Test Code: 92204
Alternate Test Names: HCV Genotype1 NS5B; NS5b Drug Resistance; Sofosbuvir Resistance
Included Tests: HCV NS5b Subtype, Sofosbuvir Resistance
CPT Coding: 87902

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