Hepatitis C Viral RNA Genotype 1 NS5b Drug Resistance

Included Tests

HCV NS5b Subtype, Sofosbuvir Resistance

Clinical Significance

For detection of mutations in the Genotype 1 NS5b gene associated with resistance to nucleotide analog NS5b polymerase inhibitors (example: sofosbuvir, a nucleotide analog inhibitor of HCV NS5b polymerase).

Specimen Requirements

2.0 mL Plasma from a Lavender Top Tube - EDTA in a Plastic Vial

Transport And Storage

72 hours Ambient
14 days Refrigerated
42 days Frozen

Collection Instructions

Separate plasma from whole blood within 24 hours of collection by centrifugation. Transfer to a plastic, screw-cap vial and refrigerate or freeze.

Minimum Volume

0.6 mL Plasma

Neonatal Volume

Reference Range:

HCV NS5b Subtype

Not detected

Methodology:

• Polymerase Chain Reaction (PCR) Sequencing

Clinical Significance

For detection of mutations in the Genotype 1 NS5b gene associated with resistance to nucleotide analog NS5b polymerase inhibitors (example: sofosbuvir, a nucleotide analog inhibitor of HCV NS5b polymerase).

CDM

00913958

CPT Coding

87902