Leflunomide Metabolite

Last Modified: 5/31/2019 7:53:02 AM

Specimen Requirements: 1.0 mL Serum from a Red Top Tube in a Plastic Vial
Minimum Volume: 0.5 mL Serum
Transport & Storage: Temperature/Stability: 5 days Ambient
14 days Refrigerated
30 days Frozen
Rejection Criteria: Serum Separater Tube (SST)
Reference Range: Refer to Interpretive Results
Methodology: LC/MS/MS
Clinical Significance: Leflunomide is an immunosuppressant medication used in the treatment of rheumatoid arthritis. Leflunomide is rapidly and extensively metabolized to teriflunomide, which is the active form of the medication. Steady state plasma concentrations in patients receiving recommended daily dosages: up to 63,000 ng/mL. It is recommended that all women of childbearing potential who discontinue leflunomide and women receiving treatment who wish to become pregnant undergo the cholestyramine drug elimination procedure. This procedure includes verification that plasma levels of teriflunomide are less than 20 ng/mL by two separate tests at least 14 days apart
Custom Panel: No


Turn Around Time: 4 to 5 days
Days Performed: Tuesday, Thursday, Saturday
Sites Performed: Quest - Chantilly to Valencia
PHL Test Code: MSOT
EPIC Test Code:
Send Out Test Code: 18865
Alternate Test Names: Leflunomide Level
CPT Coding: 80299

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