Insulin - Like Growth Factor I

Overview

  • EPIC Code:
  • LAB526
  • Soft Test Code:
  • SOMA1
  • Send Out Test Code:
  • 16293 / S51997
Alternate Names
  • IGF-1
  • IGF-I, Electrochemiluminescence
  • Insulin Growth Factor
  • Somatomedin C
  • Somatomedin IGF-1
Clinical Significance

Insulin-like growth factor I (IGF-I, or somatomedin C), a protein involved in stimulating somatic growth, is regulated principally by growth hormone (GH) and nutritional intake. IGF-I is transported in serum by several proteins; this helps maintain relatively high IGF-I plasma levels and minimizes fluctuations in serum IGF-I concentrations.

Measuring IGF-I is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone
(hypopituitarism) results in decreased serum levels of IGF-I, while acromegaly (growth hormone excess) results in
elevated levels of IGF-I. IGF-I measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet.


Specimen Collection & Preparation

Specimen Requirements

1.0 mL Serum from a Red Top Tube in a Plastic Vial


Transport And Storage

48 hours Ambient
5 days Refrigerated
7 days Frozen


Collection Instructions

Allow blood to clot (10-15 minutes) at ambient temperature
Separate serum from cells 
Freeze Serum


Minimum Volume

0.5 mL Serum


Neonatal Volume

Clinical Interpretation

Reference Range:

Refer to Interpretive Results
 


Methodology:
  • Liquid Chromatography / Mass Spectrometry (LC/MS)
Clinical Significance

Insulin-like growth factor I (IGF-I, or somatomedin C), a protein involved in stimulating somatic growth, is regulated principally by growth hormone (GH) and nutritional intake. IGF-I is transported in serum by several proteins; this helps maintain relatively high IGF-I plasma levels and minimizes fluctuations in serum IGF-I concentrations.

Measuring IGF-I is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone
(hypopituitarism) results in decreased serum levels of IGF-I, while acromegaly (growth hormone excess) results in
elevated levels of IGF-I. IGF-I measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet.


Production Schedule

Sites Performed
  • Quest - Chantilly to San Juan Capistrano
Days Performed
Monday
Tuesday
Wednesday
Thursday
Friday
Departments
  • Sendouts - Clinical
Turn Around Time

5 to 8 days


Coding & Compliance

CDM

01422828


CPT Coding

84305