Last Modified: 2/20/2023 2:29:21 PM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 5 mg small bowel biopsy collected in a 2 mL cryovial polypropylene screw-capped tube

Collection Instructions: The tissue should not be placed on gauze or filter paper, nor should any saline, support or embedding material be added

Place 5 mg (2 mg minimum) small bowel biopsy on the interior surface of a 2 mL polypropylene screw-capped cryovial or small polypropylene collection tube.

Freeze within 2 hours of collection
Minimum Volume: 2 mg tissue
Transport & Storage: Temperature/Stability: Unacceptable Ambient
Unacceptable Refrigerated
31 days Frozen
Rejection Criteria: Samples frozen later than 2 hours post-collection • Samples received in urine containers • Samples immersed in a colorless fluid (i.e., water, formalin, saline, etc.) • Samples placed on gauze, filter paper or any other type of support media
Reference Range:
Lactase 15.0-45.5 uM/min/g prot
Sucrase 25.0-69.9 uM/min/g prot
Maltase 100.0-224.4 uM/min/g prot
Palatinase 05-26.3 uM/min/g prot
Critical Ranges:  
Test Comments:  
Methodology: Spectrophotometry (SP)
Clinical Significance: Lactase, maltase, palatinase and sucrase are mucosal disaccharidases that are present in normal small intestine and fetal colon. A decrease in the enzyme activity of these disaccharidases has been noted in colonic adenomas, adenocarcinomas and malabsorption. Decreased disaccharidase activity is a good indication of mucosal injury with the exception of lactase
Custom Panel: No


Turn Around Time: 2 to 4 days
Days Performed: Sunday, Monday, Tuesday, Wednesday, Thursday
Sites Performed: Quest - Chantilly
PHL Test Code: MSOT
EPIC Test Code: MISC
Send Out Test Code: 19701
Alternate Test Names: Disaccharidase Analysis; Disaccharidase Assay; Disaccharidase Assay, Tissue; Disaccharidase Determination; Disaccharide
Included Tests: Lactase level, Maltase level, Palatinase level, Sucrase level
CPT Coding: 82657 x 4

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