Multiple Sclerosis Evaluation

Last Modified: 4/4/2011 12:42:44 PM


Specimen Requirements: 3.0 mL CSF in a Sterile Plastic Vial
and
3.0 mL Serum from a Red Top Tube in a Plastic Vial
Collection Instructions: Serum and CSF samples should be drawn on same day for most reliable results

If multiple testing is required for the CSF specimen, please list the testing priorities on the order
Minimum Volume: 2.0 mL
Transport & Storage: Temperature/Stability: 7 days Refrigerated
1 month Frozen
Reference Range:
Albumin: 3700 - 5410 mg/dL
Albumin CSF: < 35 mg/dL
Albumin Index: < 9.0
CNS IgG Synthesis Rate: <3.3 mg/24 hr
IgA CSF: 0.15 - 6.1 mg/dL
IgA (loc): < .010 mg/dL
IgA Total: 
< 1 years: 8 - 90   
< 2 years: 14 - 106  
< 3 years: 14 - 123  
< 4 years: 22 - 159  
< 6 years: 25 - 154  
< 9 years: 33 - 202  
< 11 years: 45 - 236  
>= 11 years: 70 - 315

IgG Index: < .70
IgG (loc): < .10 mg/dL
IgG Total:
< 9 months:    215 - 905 
< 2 years:     295 - 1050
< 4 years:     420 - 1200
< 6 years:     460 - 1280
< 8 years:     630 - 1280
< 14 years:    610 - 1570
>= 14 years:   600 - 1600 
IgG Total CSF: 0.5 - 6.1 mg/dL

IgM CSF: < .10 mg/dL
IgM (loc): < .010 mg/dL
IgM Total: 
< 9 months:    215 - 905 
< 2 years:     295 - 1050
< 4 years:     420 - 1200
< 6 years:     460 - 1280
< 8 years:     630 - 1280
< 14 years:    610 - 1570
>= 14 years:   600 - 1600

Myelin Basic Protein CSF: < 4.1 mcg/L
MBP Interpretation
0 - 4.0 ng/mL Negative 
4.1 - 6.0 ng/mL Weakly Positive
> 6.0 ng/mL Positive

Oligoclonal Bands in CSF: < 2 bands
Methodology: IEF / RIA / NEPH / Calculation
Clinical Significance: Used to support diagnosis of multiple sclerosis and to provide a monitor of treatment efficacy. Also useful in patients with silicone gel implants who may have M.S.-like symptoms
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 3 to 5 days
Days Performed: Sunday, Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest Valencia (SLI)
PHL Test Code: MSPRO
Send Out Test Code: 1055
Included Tests: Albumin; Albumin CSF; Albumin Index; CNS IgG Synthesis Rate; IgA CSF; IgA (loc); IgA Total; IgG Index; IgG (loc); IgG Total; IgG Total CSF; IgM CSF; IgM (loc); IgM Total; Myelin Basic Protein CSF; Oligoclonal Bands in CSF
CPT Coding: 82040, 82042, 82784 x 6, 83873, 83916

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