Medical Necessity Documentation:
Client Notes:
Patient Preparation:
Specimen Requirements:
4.0 mL CSF in a #4 CSF Collection Sterile Plastic Vial
and
2.0 mL Serum from a Red Top Tube in a Plastic Vial
Collection Instructions:
Serum and CSF samples should be drawn on same day for most reliable results
If multiple testing is required for the CSF specimen, please list the testing priorities on the order
It is preferred that the collection date and time be the same for both CSF and Serum; however it is acceptable for them to be drawn within 48 hours of each other. CSF must be crystalline and clear.
Blood contamination and hemolysis may interfere with results. Submitting 4th lumbar puncture collection tube minimizes blood contamination.
Minimum Volume:
1.0 mL Serum & 1.8 mL CSF
Transport & Storage: Temperature/Stability:
8 hours Ambient (Not accepted)
5 days Refrigerated
14 days Frozen
Refrigerated CSF at 2-8°C in sterile, plastic CSF vials, and send refrigerated (Cold Packs) to lab
or
Freeze CSF specimens at -20°C and send frozen to the lab on dry ice.
Rejection Criteria:
Received room temperature • Xanthochromia (yellowish appearance) • RBCs • Hemolysis in CSF
Reference Range:
See interpretive report
Critical Ranges:
Test Comments:
Methodology:
Isoelectric Focusing (IEF) • Nephelometry • Radioimmunoassay (RIA)
Clinical Significance:
Patients with Multiple Sclerosis (MS) have multiple, scarred areas of the brain. Symptoms can initially be mild but typically lead to relapsing or progressive incapacitating neuromotor dysfunction.
Documentation:
Useful in the diagnosis of Multiple Sclerosis.
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
4 to 5 days
Days Performed:
Monday, Tuesday, Wednesday, Thursday, Friday
Sites Performed:
Quest - Chantilly
PHL Test Code:
MSPN2
EPIC Test Code:
IMO101
Send Out Test Code:
7085
Alternate Test Names:
MS; MS Panel 2; MS Profile 2; MSPRO; Multiple Sclerosis Evaluation; Multiple Sclerosis Panel 2; Multiple Sclerosis Profile
Included Tests:
Albumin (CSF and Serum); IgG (CSF and Serum); IgG Synthesis Rate/Index CSF; Myelin Basic Protein; Oligoclonal Bands CSF.
CPT Coding:
82040, 82042, 82784 (x2), 83873, 83916