Last Modified:
8/31/2023 3:18:26 PM
Medical Necessity Documentation:
Client Notes:
Patient Preparation:
Specimen Requirements:
2.0 mL Plasma from a Lavender Top Tube - EDTA in a Plastic Vial
Collection Instructions:
Separate plasma (preferred) from whole blood within 24 hours of collection by centrifugation at 800-1600 x g for 20 minutes at room temperature.
Transfer the plasma to a properly identified, sterile, polyproprylene screw-cap vial and ship refrigerated or frozen.
Please note: HCV genotype 1 is required for this test.
Minimum Volume:
0.6 mL Plasma
Transport & Storage: Temperature/Stability:
72 hours Refrigerated
42 days Frozen (Transport)
Rejection Criteria:
Gross hemolysis • Gross lipemiaSpecimens using heparin as the anticoagulant • Ambient
Reference Range:
Refer to Interpretive Results
Critical Ranges:
Test Comments:
Methodology:
Polymerase chain reaction (PCR) • Sequencing
Clinical Significance:
This assay may be used to detect grazoprevir, simeprevir and paritaprevir resistance-associated NS3 mutations in genotype 1 NS3 protease inhibitor treatment-experienced patients and also the Q80K polymorphism in patients being considered for a simeprevir-containing regimen.
Documentation:
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
4 to 11 days
Days Performed:
Monday
PHL Test Code:
HCN53
EPIC Test Code:
LAB3007
Send Out Test Code:
90924
Alternate Test Names:
Boceprevir Resistance; HCV NS3; NS3 Protease Mutations; NS3 Subtype,HCV; Q80K Polymorphism; Simeprevir Resistance; Telaprevir Resistance
Included Tests:
CPT Coding:
87903
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